Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium
Identifieur interne : 000920 ( Main/Exploration ); précédent : 000919; suivant : 000921Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium
Auteurs : Eva Böttcher-Friebertsh User [Allemagne] ; Hans-Dieter Klenk [Allemagne] ; Wolfgang Garten [Allemagne]Source :
- Pathogens and Disease [ 2049-632X ] ; 2013.
Abstract
Influenza is an acute infection of the respiratory tract, which affects each year millions of people. Influenza virus infection is initiated by the surface glycoprotein hemagglutinin (HA) through receptor binding and fusion of viral and endosomal membranes. HA is synthesized as a precursor protein and requires cleavage by host cell proteases to gain its fusion capacity. Although cleavage of HA is crucial for virus infectivity, little was known about relevant proteases in the human airways for a long time. Recent progress in the identification and characterization of HA-activating host cell proteases has been considerable however and supports the idea of targeting HA cleavage as a novel approach for influenza treatment. Interestingly, certain bacteria have been demonstrated to support HA activation either by secreting proteases that cleave HA or due to activation of cellular proteases and thereby may contribute to virus spread and enhanced pathogenicity. In this review, we give an overview on activation of influenza viruses by proteases from host cells and bacteria with the main focus on recent progress on HA cleavage by proteases HAT and TMPRSS2 in the human airway epithelium. In addition, we outline investigations of HA-activating proteases as potential drug targets for influenza treatment.
Url:
DOI: 10.1111/2049-632X.12053
PubMed: 23821437
PubMed Central: 7108517
Affiliations:
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Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name><affiliation wicri:level="3"><nlm:aff id="fim12053-aff-0001">Institute of Virology, Philipps-University Marburg, Marburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Philipps-University Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Garten, Wolfgang" sort="Garten, Wolfgang" uniqKey="Garten W" first="Wolfgang" last="Garten">Wolfgang Garten</name><affiliation wicri:level="3"><nlm:aff id="fim12053-aff-0001">Institute of Virology, Philipps-University Marburg, Marburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Philipps-University Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author></analytic><series><title level="j">Pathogens and Disease</title><idno type="eISSN">2049-632X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Influenza is an acute infection of the respiratory tract, which affects each year millions of people. Influenza virus infection is initiated by the surface glycoprotein hemagglutinin (HA) through receptor binding and fusion of viral and endosomal membranes. HA is synthesized as a precursor protein and requires cleavage by host cell proteases to gain its fusion capacity. Although cleavage of HA is crucial for virus infectivity, little was known about relevant proteases in the human airways for a long time. Recent progress in the identification and characterization of HA-activating host cell proteases has been considerable however and supports the idea of targeting HA cleavage as a novel approach for influenza treatment. Interestingly, certain bacteria have been demonstrated to support HA activation either by secreting proteases that cleave HA or due to activation of cellular proteases and thereby may contribute to virus spread and enhanced pathogenicity. In this review, we give an overview on activation of influenza viruses by proteases from host cells and bacteria with the main focus on recent progress on HA cleavage by proteases HAT and TMPRSS2 in the human airway epithelium. In addition, we outline investigations of HA-activating proteases as potential drug targets for influenza treatment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Afar, De" uniqKey="Afar D">DE Afar</name></author><author><name sortKey="Vivanco, I" uniqKey="Vivanco I">I Vivanco</name></author><author><name sortKey="Hubert, Rs" uniqKey="Hubert R">RS Hubert</name></author><author><name sortKey="Kuo, J" uniqKey="Kuo J">J Kuo</name></author><author><name sortKey="Chen, E" uniqKey="Chen E">E Chen</name></author><author><name sortKey="Saffran, Dc" uniqKey="Saffran D">DC Saffran</name></author><author><name sortKey="Raitano, Ab" uniqKey="Raitano A">AB Raitano</name></author><author><name sortKey="Jakobovits, A" uniqKey="Jakobovits A">A Jakobovits</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baron, J" uniqKey="Baron J">J Baron</name></author><author><name sortKey="Tarnow, C" uniqKey="Tarnow C">C 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Yoshinaga</name></author><author><name sortKey="Nakahori, Y" uniqKey="Nakahori Y">Y Nakahori</name></author><author><name sortKey="Yasuoka, S" uniqKey="Yasuoka S">S Yasuoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhirnov, Op" uniqKey="Zhirnov O">OP Zhirnov</name></author><author><name sortKey="Ovcharenko, Av" uniqKey="Ovcharenko A">AV Ovcharenko</name></author><author><name sortKey="Bukrinskaya, Ag" uniqKey="Bukrinskaya A">AG Bukrinskaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhirnov, Op" uniqKey="Zhirnov O">OP Zhirnov</name></author><author><name sortKey="Ikizler, Mr" uniqKey="Ikizler M">MR Ikizler</name></author><author><name sortKey="Wright, Pf" uniqKey="Wright P">PF Wright</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhirnov, Op" uniqKey="Zhirnov O">OP Zhirnov</name></author><author><name sortKey="Vorobjeva, Iv" uniqKey="Vorobjeva I">IV Vorobjeva</name></author><author><name sortKey="Ovcharenko, Av" uniqKey="Ovcharenko A">AV Ovcharenko</name></author><author><name sortKey="Klenk, Hd" uniqKey="Klenk H">HD Klenk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhirnov, Op" uniqKey="Zhirnov O">OP Zhirnov</name></author><author><name sortKey="Klenk, Hd" uniqKey="Klenk H">HD Klenk</name></author><author><name sortKey="Wright, Pf" uniqKey="Wright P">PF Wright</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Giessen</li><li>Hesse (Land)</li></region><settlement><li>Marbourg</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Bottcher Friebertsh User, Eva" sort="Bottcher Friebertsh User, Eva" uniqKey="Bottcher Friebertsh User E" first="Eva" last="Böttcher-Friebertsh User">Eva Böttcher-Friebertsh User</name></region><name sortKey="Garten, Wolfgang" sort="Garten, Wolfgang" uniqKey="Garten W" first="Wolfgang" last="Garten">Wolfgang Garten</name><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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